Job Description

Salary: Full time starting salary is normally in the range xc2xa332,546 to xc2xa335,116 with potential progression once in post to xc2xa339,355. As this vacancy has limited funding the maximum salary that can be offered is Grade 6, salary xc2xa335,116.Contract Type: Fixed Term ContractJob SummaryAn exciting opportunity has arisen for a Research Associate to support the research activities of Professor Nadia Schoenmakers (Professor of Endocrinology). The Schoenmakers' group primarily aims to delineate the molecular basis of congenital hypothyroidism (CH), identifying known and novel genetic causes of CH in affected patients using candidate gene and exome/genome sequencing-based approaches. They then investigate the biology associated with particular genetic mutations using in vitro/ex vivo experimental techniques and murine models.The postholder will have the opportunity to analyse research data and perform and supervise a broad range of laboratory experiments, which may include characterization of mutations in genes with a role in thyroid biology using standard molecular biology techniques, and evaluation of the effects of altered gene expression, or gene mutation in heterologous or primary cultured cells. A current priority is also to investigate the thyroidal role of SLC26A7, a novel anion transporter with a key role in thyroid hormone biosynthesis in humans and mice, which the group has identified. The postholder will be involved in genotyping mouse models, and culturing and characterizing murine and human tissue samples. They may also be involved in validating a thyroid organoid model.

• Work within specified research grants and/or projects
• Operate within area of specialism
• Analyse and interpret research findings and results
• Contribute to generating funding
• Contribute to publications

Main Responsibilities

• Perform and supervise a broad range of laboratory experiments. These may include cell culture, molecular characterization and functional evaluation of primary and iPSC derived cells, functional studies in diverse cellular systems, molecular imaging, qPCR, genomic sequencing, molecular cloning, radioisotope studies, in silico analyses, and characterization of genetically-altered murine lines.
• Analyse research data as directed
• Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
• Develop or adapt techniques, models and methods
• Provide guidance as required to support staff and any students who may be assisting with research
• Deal with problems that may affect the achievement of research objectives and deadlines

Person Specification

• Degree or equivalent in relevant subject area
• Practical experience of applying the relevant skills and techniques
• Ability to analyse information and communicate effectively within and outside the immediate research group.
• Ability to access and organise resources successfully
• Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day-to-day activity in own area that those with protected characteristics are treated equally and fairly

Informal enquiries to Nadia Schoenmakers, email:To download the full job description and details of this position and submit an electronic application online please click on the 'Apply' button above.Valuing excellence, sustaining investment
We value diversity and inclusion at the University of Birmingham and welcome applications from all sections of the community and are open to discussions around all forms of flexible working.Closes: 13th April 2025xc2xa332,546 to xc2xa335,116. Grade 6

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