Job Description

:Grade UE07: xc2xa340,247 - xc2xa347,874 per annumCMVM / Institute for Regeneration and Repair / Centre for Inflammation ResearchFull-time: 35 hours per weekFixed Term dates: until 31 January 2026 - it is anticipated that a further extension may be available subject to funder approvalsWe are looking for an enthusiastic and ambitious postdoctoral research fellow with interests in neuroimmunology to help us investigate infection as a complication of stroke recovery and the neuroimmune mechanisms that underpin these changes.This post is advertised as full-time (35 hours per week) and we are open to considering flexible working patterns.The Opportunity:We are currently working on understanding the long-term consequences of stroke on the immune system and how this may relate to vulnerability to infection and cognitive outcomes after stroke. This project will use pre-clinical models of stroke combined with vaccination and/ or respiratory infection models. The project will have a focus on the adaptive immune system and include investigations of the impact of stroke on immunological memory and the role of lymphocytes in the recovering brain.Informal enquiries to Dr Laura McCulloch are welcomed ( )The research fellow will be based in the McCulloch lab within the Centre for Inflammation Research ( ). CIR is within the Edinburgh Bioquarter campus which hosts a rich local immunology, neuroscience and vascular community co-located on a major biomedical and health research campus ( ).Your skills and attributes for success:

• You will have a PhD (or PhD near completion) or equivalent qualification in a relevant biomedical science and ideally have deep knowledge, interests and skills in neuroimmunology, cerebrovascular disease, respiratory infection or adaptive immune biology
• Experience in general in in vivo procedures
• Experience in immune cell isolation and downstream immunophenotyping e.g. flow cytometry, -omics profiling
• Expertise in relevant approaches and models, analytical techniques and methods e.g. immunohistochemistry, microscopy, ELISA, qPCR, statistical approaches
• Ability to communicate complex information clearly, orally and in writing.

Click to view a copy of the full (opens new browser tab)As a valued member of our team, you can expect:

• A competitive salary.
• An exciting, positive, creative, challenging and rewarding place to work.
• To be part of a diverse and vibrant international community.
• Comprehensive Staff Benefits, such as a generous holiday entitlement, a defined benefits pension scheme, staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our

(opens in a new tab) and use our reward calculator to discover the total value of your pay and benefits.Championing equality, diversity and inclusionThe University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our (opens new browser tab).On this occasion the University will not consider applicants requiring sponsorship for this role. International workers will therefore only be able to take up this role if they can demonstrate an alternative right to work in the UK.Key notes for applicantsAs part of this application, you are required to upload a cover letter/statement of not more than one page detailing how you meet each of the essential criteria as outlined on the job description and a CV.The closing date for applications is 6 March 2025.Unless stated otherwise the closing time for applications is 11:59pm GMT. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone.We anticipate that interviews will be held within 2-3 weeks of the advert closing date.About Us: As a world-leading research-intensive University, we are here to address tomorrow's greatest challenges. Between now and 2030 we will do that with a values-led approach to teaching, research and innovation, and through the strength of our relationships, both locally and globally.About the Team:The Centre for Inflammation Research (CIR; Director, Professor David Dockrell) leverages peer-reviewed interdisciplinary research programmes and focussed collaboration, to characterise mechanisms of acute and chronic inflammation. CIR aims to characterise what promotes health at the molecular level in order to prevent the harmful consequences of inflammation in clinical medicine. Effort is targeted at: inhibiting the initiation of inflammation by blocking specific molecular triggers and by modulating cellular and tissue responses resulting in organ dysfunction; finding new approaches to modulate established inflammatory responses to limit tissue injury; and promoting safe resolution of inflammation to restore healthy structure and function of tissue.The CIR has a broad interest in inflammatory disease in a range of tissues including in the lungs, kidney, liver, pancreas, bowel, bone, joints, skin, heart and brain. There is in-depth analysis of stimuli that induce or modify inflammation with detailed programmes considering the role of sex, development, auto-immunity, infection and other environmental influences. Importantly, the principles derived will have ready application to inflammatory and reparatory responses in virtually all physiological and pathological settings, including cancer and infection (not least COVID-19). Translation is aided by a commitment to novel diagnostic and imaging modalities and our proximity to patient groups and healthy volunteers in the Royal Infirmary, Edinburgh.Our research aims align closely with the vision of IRR and other centres within IRR, to promote human health through in-depth understanding of tissue regeneration and repair, while developing a multi-pronged translational programme to effect therapeutic innovation in this area. IRR is located on the BioQuarter Campus, Edinburgh.

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