Job Description

We are seeking to appoint a Postdoctoral Research Assistant with expertise in endo-lysosomal biology and iPSC-derived neuronal cultures to join the Alzheimer\xe2\x80\x99s Research UK Oxford Drug Discovery Institute (ARUK-ODDI) at Centre for Medicines Discovery, Nuffield Department of Medicine.

You will become an integral part of the Organelle Biology team within the ODDI and report to the team leader (Dr Margarida Ruas). As an experienced molecular and cell biologist with a background in neurodegeneration, you will be responsible for designing and executing experimental plans to support the validation of targets, and the discovery of novel therapeutic agents. You will be expert in several cutting-edge methodologies (iPSC-derived neuronal cells, high content imaging, ratiometric fluorescent reporters) and be able to provide scientific and technical advice to students and colleagues within the ARUK-ODDI, or collaborating academic groups. You will provide the experimental and analytical expertise required to prosecute target validation and drug discovery for mechanisms regulating subcellular trafficking and organelle homeostasis in the context of Alzheimer\xe2\x80\x99s and Parkinson\xe2\x80\x99s disease.

It is essential that you hold a PhD/DPhil (or close to completion) in Cell Biology or related subject, together with significant research experience relevant to the field of endo-lysosomes and subcellular trafficking. You will also have experience in cell culture, including human iPSC-derived neuronal lines, and manipulation of cell lines by lentiviral transduction and transfection for manipulation of gene expression (e.g. siRNA, CRISPRi/a, overexpression). You will have excellent attention to detail and ability to work as part of a team and of productive collaborative research, with excellent communication skills.

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

This position is offered full time on a fixed term contract until 31 October 2025, with possibility of extension and is funded by the Alzheimer\xe2\x80\x99s Research UK.

Only applications received before 12 midday on 8 January 2024 will be considered. Please quote 168235 on all correspondence.