Job Description

Site Name: UK - Hertfordshire - Stevenage
Posted Date: Dec 1 2023

Director, Molecular Safety

Accountable for leading and managing a UK based team focused on the application of cellular and molecular approaches to elucidate mechanisms of toxicity, understanding species differences, identifying novel translational safety biomarkers, and informing project decisions. The specialist capabilities of the team, with emphasis on cellular, molecular (multiomics), and Next generation Sequencing (NGS) techniques, are applied from discovery through post-registration. Delivery of investigative toxicology assessments at various stages of drug discovery and development is a critical requirement for project team decision-making, patient safety and meeting regulatory expectations. Annual Report 2021

Key Responsibilities

• Provide accountable leadership and management of a team of scientists to ensure effective application of molecular and Omics capabilities (i.e., transcriptomics, proteomics, metabolomics, etc.) to address mechanisms of toxicity and support project teams in GSK R&D Worldwide. The work includes advising, planning, designing, and interpreting findings from investigate molecular safety studies including advanced sequencing (e.g., massively parallel sequencing, single cell RNAseq, spatial transcriptomics), multi-omics, cellular assays, and biomarkers of toxicity.
• Establish and oversee data generation workflows (e.g., sample preparation to enable sequencing or multi-omics data generation, data analysis and reporting) to ensure data and reports are of high quality and build confidence in GSK\xe2\x80\x99s integrity and scientific credibility with internal partners, external reviewers, and Regulatory Authorities.
• Establish a strategic vision for the use of molecular safety technologies to shape the future of non-clinical safety assessment and inform regulatory decision-making supported by the development of strong partnerships with aligned technology and computational/data/bioinformatics science colleagues in R&D and externally.
• Facilitate application of advanced technologies, analysis, and integration of complex high content datasets for investigative safety purposes and elucidate mechanism of action (MoA) and support human and/or in vitro-in vivo translation.
• Attract, develop, and retain diverse talented scientists to establish and maintain a highly motivated, productive, and innovative science platforms that build on best practices to continuously improve strategies and tactics, and be cognisant of external regulatory guidance/expectations/strategies.
• Define molecular / multi-omics / NGS scientific strategy 12 - 18 month planning horizon with responsibility for execution of strategy in own area. To include scientific relationships that encourage collaborations (with internal and external partners) to guide the development and deployment of new molecular / multi-omics / NGS approaches to improve the efficiency, prediction, mechanistic understanding, and translation of drug safety risks and leveraging internal/external data resources e.g.TG-Gates, EMBI-EBI, NIH preclinical species gene expression databases, etc.
• Ensure compliance with SOPs and Policies, GLP, data integrity, safety, and animal welfare guidelines.

Closing Date for Applications \xe2\x80\x93 [15th December 2023] (COB) Please take a copy of the , as this will not be available post closure of the advert.
When applying for this role, please use the \xe2\x80\x98cover letter\xe2\x80\x99 of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
During the course of your application, you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process. Why you? Qualifications & Skills: Basic Qualifications:

• PhD in Molecular biology, Cellular biology, Toxicology and/or other related biological science, ideally with experience of a drug discovery and development environment or Research Institute Organisation.
• BSc in Life Sciences, Biomedical Sciences
• Experience leading, developing, motivating, and performance managing a team responsible for delivering molecular biology, cellular biology and/or advanced investigative safety science to Pharmaceutical R&D projects, including delivery of studies internally and with CRO partners.
• Proven ability of integrating and contextualising target, pathway, molecule, disposition, and safety data to design and deliver experiments and strategies focused on predictive and mechanistic human-relevant safety.
• Ability to work routinely across boundaries and establish cross functional matrix collaborations and teams.
• Ability to coach/mentor, develop and performance manage staff.
• Advanced communications skills and ideally with a relevant publication record
• Familiar with Platform, Data and Bioinformatics software and working with data analysts/bioinformaticians to leverage and integrate multi-omics approaches to support toxicological MOA and risk assessment.

Preferred Qualifications:

• Extensive knowledge of molecular and Omics technology platforms.
• Extensive knowledge of NGS platforms and data analysis methods.
• Experience advising on investigative safety and/or advanced Omics technology applications and designing associated studies.
• Use of Omics data to support Adverse Outcome Pathways.
• Ideally with ability to code in R or Python to deliver bespoke data solutions as required.

Why Us? GSK is a global biopharma company with a special purpose \xe2\x80\x93 to unite science, technology and talent to get ahead of disease together \xe2\x80\x93 so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns \xe2\x80\x93 as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030. Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it\xe2\x80\x99s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We\xe2\x80\x99re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce. As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only). We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are. Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on Ukdiversity.recruitment@gsk.com or 0808 234 4391. Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK\'s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK\xe2\x80\x99s compliance to all federal and state US Transparency requirements. For more information, please visit GSK\xe2\x80\x99s Transparency Reporting For the Record site.