Job Description

Do you have expertise in, and passion for therapeutic antibody discovery? Would you like to apply your expertise to impact the next generation biotherapeutics portfolio in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

AstraZeneca

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you\xe2\x80\x99re our kind of person.

Business Area

In Biologics Engineering, we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease.

The Biologics Engineering team is responsible for the discovery and optimisation of biological candidate drugs to support all therapy area drug discovery pipelines and for the development of in-house biologics discovery platforms and novel drug modalities to support future drug discovery efforts.

Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions \xe2\x80\x93 innovating, challenging accepted norms, quick decision-making and taking smart risks. A place of trust, it\xe2\x80\x99s an opportunity to take accountability, be brave, speak up, step up and be a part of improving lives, this is the time to join the team who discovers tomorrow\'s biotherapeutics today.

The Role

We are seeking a highly motivated Associate Principal Scientist to help support our Respiratory and Immunology discovery pipeline, developing and implementing our next-generation modalities in their application to pre-clinical programs. The successful candidate will add to our team of multidisciplinary and hard-working scientists excited by research at the interface between technology and biology.

We are looking for a well-organized and a highly productive bench scientist that can design and execute experiments efficiently, as well as analyse, interpret, and present data and ideas to a wider audience. The role will require the candidate to apply biophysical, protein and molecular biology skill sets, to design and characterise the next generation of biologics, with a focus on multi-specific molecules.

Education & Experience Requirements:

A Ph.D level scientist with significant post-doctoral experience, or Batchelor\xe2\x80\x99s degree with significant experience in an industry setting

Required Skills:

Deep understanding of antibody structure-function relationships, leading to innovation in the field as evidenced by publications and/or patents

Experience in protein design, production and characterisation of antibodies, or antibody-like scaffolds, using in silco tools, common expression systems (e.g. mammalian) and purification methods (e.g. Akta systems), and the ability to profile constructs (e.g. SPR)

Strong hands-on experience in molecular biology methods and technologies e.g., PCR, RT-PCR, cloning (ligation-dependent and independent methods), site-directed mutagenesis, Sanger sequencing/analysis

Ability to optimize protocols, troubleshoot, interpret experimental results/data and maintain accurate, high quality and up-to-date experimental records

Strong communication skills in a team environment and an ability to quickly learn and adopt new technologies

Experience with leading/co-leading and/or handling research projects.

Desired Skills:

Background in molecular biophysics

Experience with single domain antibodies

Background in drug discovery and development in the pharmaceutical industry

Experience supervising Postdocs and/or placement students

Location: Cambridge, UK

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we\xe2\x80\x99re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what\xe2\x80\x99s next!

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it\xe2\x80\x99s yours.

Where can I find out more?

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Date Posted 28-Jul-2023

Closing Date 10-Aug-2023

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca