Job Description

Amphista Therapeutics is a fast-growing Cambridge-based biotech and the leading European Targeted Protein Degradation (TPD) company. Our unique scientific approach to TPD, one of the hottest areas in modern drug discovery, gives us a range of advantages over other therapeutic strategies. Initially founded from the laboratory of Professor Alessio Ciulli (University of Dundee) our team comprises both academic and drug discovery pioneers of the TPD field and a growing R&D team focused on advancing a portfolio of medicines to the clinic using our proprietary next generation TPD technologies.

We have completed an oversubscribed $53M funding round which was recently extended with investment by the Dementia Discovery fund. During 2022 we were delighted to announce in two separate collaboration deals with Bristol Myers Squibb and Merck Healthcare which will allow us to grow and advance our therapeutic portfolio even faster. This excellent progress has been recognised Amphista named as a Fierce Biotech, Fierce15 winner for 2022.

The Associate Director Biology will be responsible for managing a team of scientists to contribute to the successful delivery of multiple Amphista discovery projects. The successful candidate will be experienced in the area of oncology and will take advantage of the unique benefits of Amphista technology to develop novel medicines to addressing targets or pharmacology not achievable with conventional small molecules or standard TPD approaches.

The ideal candidate will be goal oriented, a creative problem solver, clear thinking with excellent communication skills and an ability to engage their own team and the broader R&D team around them.

In their role, they will also attend and represent Amphista at scientific and industry-led meetings.

Leadership and Management

• Lead scientists to achieve project goals, with a focus on quality and deep mechanistic understanding, within the agreed timelines.
• Ensure team pays attention to scientific detail, understands project rationale, executes at pace, performs data analysis and interpretation,

and is able to communicate the results and their significance to the broader team.

• Ability to work across functions to optimise processes and activities.
• Responsible for leading, motivating and developing staff. Undertake regular reviews, provide advice, support and training & development

for direct reports.

• Clear and regular communication to team and leadership of project progress and organizational priorities.
• Maintain awareness of the internal & external developments in the Oncology field and apply these to Amphista projects.

Operational and Technical

• Work with project management and R&D leadership team to ensure therapeutic programs are progressed and delivered to plan.
• Responsible for monitoring, measuring and reporting on scientific issues, opportunities and developmental plans and achievements

within agreed formats & timescales.

• Create and present plans and results in a range of verbal and written channels to Amphista R&D leadership and programme teams,

including preparing and writing-up protocols, methods and reports as required.

• Responsible as an R&D leader for ensuring all activities, records and data are clearly recorded, kept up to date and in compliance with

regulatory and H&S requirements.

• Identification and management of appropriate CRO\xe2\x80\x99s who can drive biological understanding of Amphista technology and mechanisms.
• Critically analyse project data and contribute ideas that will drive projects forward whilst maintaining an awareness of current

developments in the literature to support projects.

• Presenting and communicating plans and results internally and, when needed, externally.

• Degree or PhD in Biology, Pharmacy, or related pharmaceutical science.
• Deep mechanistic understanding and awareness of emerging opportunities in therapies for Oncology.
• Industry experience in developing small molecule therapeutics in Oncology (biotech or pharmaceutical company)
• Track record of advancing and leading projects from concept through drug discovery milestones, ideally in fast-paced environment.
• Experience leading and managing Research Biologists, ensuring rigorous data analysis and developing the careers of team members.
• Experience working across disciplines and an ability to effectively work outside own line/area of expertise.
• Excellent communication and presentation skills

What\xe2\x80\x99s on offer

• Competitive salary
• Discretionary bonus scheme
• Growth Shares
• Pension
• Flexible Benefits Scheme

More about Amphista

Amphista\xe2\x80\x99s approaches use completely novel mechanisms to build on all the advantages of TPD while directly addressing the emerging limitations of existing TPD strategies to expand the utility of the field. We have shown our approach has the potential to be superior to all other TPD approaches (PROTACs, molecular glues etc) improved druglike properties and reduced tumour resistance potential. We have a range of projects in the discovery phase, initially focused on oncology with potential to expand into other therapy areas including CNS disease & immunology.

Initially founded from the laboratory of Professor Alessio Ciulli (University of Dundee) our team comprises both academic and drug discovery pioneers of the TPD field and a growing R&D team focused on advancing a portfolio of medicines to the clinic using our proprietary next generation TPD technologies. We are continuing to grow and are looking for a key hire to expand our screening and assay teams.

The Amphista team comprises highly experienced drug discovery and TPD experts across both biology and chemistry disciplines, creating the ideal learning environment to advance your scientific career development quickly. This is an exciting opportunity to join a fast growing and dynamic company operating at the cutting edge of protein degradation-based drug discovery to develop first-in-class medicines to treat cancer and other areas of high unmet medical need.

Amphista Therapeutics Ltd