Job Description

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity\xe2\x80\x99s greatest challenges.

About the Role

We are seeking an Advanced Research Assistant for the multi-omic profiling of the human skin during development and disease. This position is for a 3-year fixed term contract.

You will be responsible for:

You will be embedded in the and primarily support the research activities of the You will participate in exciting projects that are using cutting-edge technologies to multi-omically map the human skin during disease progression and response to drug interventions for a variety of dermatological conditions in adult skin, and during development. You will have the opportunity to support other exciting projects including the Human Cell Atlas work being undertaken in Cellular Genetics.

You will play a fundamental role within the team, implementing pioneering genomic technologies and bespoke sequencing library creation for gene expression, immune cell profiling and chromatin accessibility analysis of single cells or nuclei in preparation for downstream NGS analysis, using protocols. You will use multiple sample and data trackers to carefully keep track of important experimental metadata. You will be involved in supporting the day-to-day management of the lab, including monitoring of resources, reporting equipment and experiment faults, and assist in troubleshooting.

Excellent communication and relationship-building skills alongside strong time management and organisational skills are needed as is the ability to troubleshoot and identify areas for process improvement.

About Us:

The Haniffa group is part of the Human Cell Atlas initiative, a global collaboration that aims to create a comprehensive reference map of the human body by mapping every cell. The data generated will provide a vital foundation for understanding human health and diagnosing, monitoring, and treating disease. You will be embedded in the Cellular Genetics Wet Lab Support Team and largely work towards the Haniffa team\xe2\x80\x99s research goals, however, being part of a core team in the programme, you will also have the opportunity to contribute to other exciting research themes across the Cellular Genetics faculty research groups.

About you:

You are expected to bring basic molecular biology skills to this role. You will be trained in a variety of including but not limited to; single cell and single nuclei RNA sequencing, ATAC-seq, CITE-seq and Visium. The role will require you to be adaptable and have excellent interpersonal and communication skills to closely coordinate with the Scientific Managers, Staff Scientists and other members of the team leading and working on these projects.

Essential Skills:

Degree or equivalent experience in a biological science.

Tissue dissociation, DNA/RNA extraction, qRT-PCR

Ability to test, implement, and troubleshoot new techniques and protocols.

Excellent communication skills

Good attention to detail and record keeping for sample and experimental tracking

Motivation and ambition to make a personal contribution to GRL research

Excellent communication skills to allow efficient interactions with collaborators

Team player with the ability to work with others in a collaborative environment

Ability to work to a schedule and successfully manage and prioritise multiple incoming projects

Ability to effectively prioritise, multi-task and work independently

Demonstrates inclusivity and respect for all

Desirable Skills:

Writing and reviewing SOPs

Writing and reviewing risk assessments

Histology experience with tissue preservation (e.g., fixation, cryopreservation) and cryosectioning.

Experience with histological imaging methods.

Experience with working with the Human Tissue Act.

Other Information:

Salary per annum: \xc2\xa331,739-\xc2\xa337,707 depending on experience.

Closing Date: 3rd September 2023

Application Process:

Please apply with your CV and a cover letter in which you summarise your relevant laboratory work experience (referring to the information above) and detail your motivation for applying for this role.

We will be aiming to interview w/c 11th September 2023.

Working at Wellcome Sanger:

Our flexible-hybrid working environment is designed to support a healthy work-life balance. This means you can work flexibly with a combination of working from home, and working from our Campus to allow you to focus on being productive and part of the team while enjoying the benefits of working flexibly.

We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a with the following staff networks, LGBTQ+, Parents and Carers and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.

We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That\xe2\x80\x99s why we\xe2\x80\x99re committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Our Benefits:

We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.

Wellcome Sanger Institute